{"id":338,"date":"2015-08-26T04:29:07","date_gmt":"2015-08-26T04:29:07","guid":{"rendered":"https:\/\/science.sjp.ac.lk\/che\/?page_id=338"},"modified":"2025-04-22T03:37:29","modified_gmt":"2025-04-22T03:37:29","slug":"dr-n-t-perera","status":"publish","type":"page","link":"https:\/\/science.sjp.ac.lk\/che\/dr-n-t-perera\/","title":{"rendered":"Prof. N. T. Perera"},"content":{"rendered":"
\"theshi\"<\/a><\/h5>\n

Professor<\/strong><\/p>\n

B.Sc. (Honors) (Colombo), Ph.D.(Louisiana State University, USA)<\/p>\n

Download Full CV >><\/strong><\/a><\/h4>\n

Biosketch:<\/strong><\/p>\n

B.Sc. – University of Colombo\/Sri Lanka\/2004
\nPh.D. – Louisiana State University\/USA\/2010<\/p>\n

Research interest :<\/strong><\/p>\n

Synthesis of novel metal based therapeutics to curb cancer
\nDevelopment of non invasive, convenient and sub cellular level detection probes for the diagnosis of cancer
\nSynthesis of organic ligands and inorganic complexes (Re, Pt, Zn, Cu and Ru) of biomedical relevance<\/p>\n

Selected Publications:<\/strong><\/p>\n

Kaluthanthri, D;\u00a0Rajagopalan, U.; Fronczek, F.R; Samarakoon, S.R.; Weerasinghe L;\u00a0Perera, I.C.; Perera, T<\/strong>; \u201cSynthesis and characterization of sulfonamide appended rigid phenyl-based and non-rigid 1,4-benzodioxan-based ring systems and their Pt (II) complexes towards potential therapeutic targets\u201d, Polyhedron 255 (2024) 117131 (doi.org\/10.1016\/j.poly.2024.117131) (IF = 2.4)<\/strong><\/p>\n

Kaluthanthri, D;\u00a0Perera, T;<\/strong> Fronczek, F.R; \u201cSynthesis, spectroscopic analysis and crystal structure of(N-{<\/em>2-[(2-aminoethyl)amino]ethyl}<\/em>-4_<\/em>-methyl-[1,1_<\/em>-biphenyl]-4-sulfonamidato)tricarbonylrhenium(I), Acta Cryst. (2024). E80<\/strong>, 742\u2013745 (IF = 0.9)<\/strong><\/p>\n

Maladeniya, C; Darshani, Taniya; Samarakoon, S.S.; Fronczek, F.R.; Sameera, W.M.C.; Perera I C; Perera, Theshini<\/strong>, \u201cBiological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity\u00a0 and Biological Imaging\u201d\u00a0 Bioinorganic Chemistry and Applications 2022 (IF = 4.7)<\/strong><\/p>\n

K.V.N.N. Vitharana, C. Kaushalya, N.T. Perera<\/strong>, W,M.C. Saneera, A. Cooray, S.P. Deraniyagala, \u201cDipicolylamine-based Fluorescence Probes and Their Potential for the Quantification of Fe3+<\/sup> in Aqueous Solutions\u201d ACS Omega 2022 (IF = 4.1)<\/strong><\/p>\n

Mauran, S.; Perera, N.T.<\/strong>; Perera, I.C. \u201cMxyR of Mycobacterium tuberculosis responds to xylan; an unusual ligand for a MarR family transcriptional regulator\u201d Molecular Biology, 2021, 56 (1) (IF = 1.5)<\/strong><\/p>\n

Thushara, Nadini; Darshani, T.; Samarakoon, SR;\u00a0 Perera, IC; Fronczek, Frank R; Sameera, WMC.; Perera, Theshini<\/strong> \u201cSynthesis, Characterization and Biological Evaluation of Dipicolylamine Sulfonamide Derivatized Platinum Complexes as Potential Anticancer Agents\u201d RSC Advances 2021 (IF = 3.9)<\/strong><\/p>\n

Darshani, Taniya; Fronczek, Frank R.; Priyadarshani, <\/sub>V V; \u00a0<\/sup>Samarakoon, S; Perera, IC; Perera, Theshini<\/strong>. \u201cSynthesis and Characterization of Novel Napththalene-derivatized Tridentate Ligands and their Net Neutral Rhenium Tricarbonyl Complexes\u00a0 as Potential Therapeutic Agents for Lung Cancer\u201d Polyhedron 2020 (IF = 2.4)<\/strong><\/p>\n

Darshani, Taniya; Fronczek, Frank R.; Priyadarshani, <\/sub>V V; \u00a0<\/sup>Samarakoon, S; Perera, IC; Perera, Theshini<\/strong>. \u201cSynthesis and Characterization of Novel Napththalene-derivatized Tridentate Ligands and their Net Neutral Rhenium Tricarbonyl Complexes\u00a0 as Potential Therapeutic Agents for Lung Cancer\u201d Polyhedron 2020<\/p>\n

Darshani, Taniya; Thushara, Nadini; Weerasuriya, Piyumali; Fronczek, Frank R.;\u00a0 Perera, IC; Perera, Theshini<\/strong>. \u201cFluorescent di-(2-picolyl) amine based drug-like ligands and their Re (CO) 3 complexes towards biological applications<\/a>\u201d Polyhedron 2020<\/p>\n

Darshani, Taniya; Weldeghiorghis, Thomas, K.; Fronczek, Frank R.; Perera, Theshini. The first structurally characterized sulfonamide derivatized Zn (II)-dipicolylamine complexes with eight membered chelate rings. Synthetic and structural studies<\/a>, Journal of Molecular Structure<\/p>\n

Katugampala, S; Nanayakkara, C; Perera I C; Perera, T<\/strong> \u201cSynthesis, Characterization and Antimicrobial Activity of Novel Copper – triazine Complexes\u201d Bioinorganic Chemistry and Applications,\u00a0 2018<\/p>\n

Abeydeera, N; Perera I C; Perera, T<\/strong> \u201cSynthesis, Characterization and BSA Binding Studies of Novel Zinc – triazine Complexes\u201d Bioinorganic Chemistry and Applications, 2018<\/p>\n

Subasinghe, Amali; Perera I C; Perera, Theshini<\/strong>, \u201cSynthesis, Characterization, and Biological Studies of a Piperidinyl Appended Dipicolylamine Ligand and Its Rhenium Tricarbonyl Complex as Potential Therapeutic Agents for Human Breast Cancer\u201d; Bioinorganic Chemistry and Applications, 2016<\/p>\n

Ranasinghe, P V H K; Perera I C; Handunetti, S; Perera, Theshini, \u201cSynthesis and Characterization of Novel Rhenium(I) Complexes towards Potential Biological Imaging Applications<\/a>\u201d; Chemistry Central Journal, 2016, 10:71<\/p>\n

Perera, Theshini<\/strong>; Abhayawardhana, Pramuditha; Marzilli, Patricia A; Fronczek, Frank R.; Marzilli, Luigi G. <\/a>\u00a0\u201cFormation of a Metal-to-Nitrogen Bond of Normal Length by a Neutral Sufonamide Group within a Tridentate Ligand. A New Approach to Radiopharmaceutical Bioconjugation\u201d; Inorganic Chemistry, 2013,52, 2412-2421<\/p>\n

Perera, Theshini<\/strong>; Abhayawardhana, Pramuditha; Fronczek, Frank R.; Marzilli, Patricia A; Marzilli, Luigi G. \u201cIminoether Complexes of the Type, fac<\/em>-[Re(CO)3<\/sub>(L)(HNC(CH3<\/sub>)OCH3<\/sub>)]BF4<\/sub> (L = Bipyridine and Substituted Bipyridine): Synthesis and Properties\u201d; Europen Journal of Inorganic Chemistry 2012, 618-627)<\/p>\n

Abhayawardhana, Pramuditha; Marzilli, Patricia A;\u00a0 Perera, Theshini<\/strong>; Fronczek, Frank R.; Marzilli, Luigi G. \u201cNew Monodentate Amidine Superbasic Ligands with a Single Configuration in fac<\/em>-[Re(CO)3<\/sub>(5,5\u2032- or 6,6\u2032-Me2<\/sub>bipyridine)(amidine)]BF4<\/sub> Complexes\u201d; Inorganic Chemistry, 2012, 51, 7271\u20137283<\/p>\n

Perera, Theshini<\/strong>; Fronczek, Frank R.; Watkins, S. \u201c2,9,16,23-Tetra\u00adkis(1-methyl\u00adeth\u00adyl)-5,6,11,12,13,14,19,20,25,26,27,28-dodecadehydro\u00adtetra\u00adbenzo[a<\/em>,e<\/em>,k<\/em>,o<\/em>]cyclo\u00adeicosene\u201d; Acta Crystallographica Sec E Struct Rep Online. 2011, 67, 3493.<\/p>\n

Perera, Theshini<\/strong>; Marzilli, Patricia A; Fronczek, Frank R.; Marzilli, Luigi G. \u201cSeveral Novel N-Donor Tridentate Ligands Formed by Attack of a Terminal Amine on Coordinated Acetonitrile. Synthetic, NMR Spectral, and X-ray Crystallographic Studies of fac<\/em>-Re(CO)3<\/sub> Complexes\u201d; Inorganic Chemistry 2010, 49<\/em>, 2123-2131<\/p>\n

Perera, Theshini<\/strong>; Marzilli, Patricia A; Fronczek, Frank R.; Marzilli, Luigi G. \u201cNH NMR Shifts of New, Structurally Characterized fac<\/em>-[Re(CO)3<\/sub>(polyamine)]n+<\/sup> Complexes Probed via Outer Sphere H-Bonding Interactions to Anions, Including the Paramagnetic [Re(IV)Br6<\/sub>]2-<\/sup> Anion\u201d; Inorganic Chemistry 2010, 49<\/em>, 5560-5572<\/p>\n

Perera, Theshini<\/strong>; Fronczek, Frank R.; Marzilli, Patricia A; Marzilli, Luigi G. \u201cSuperbasic Amidine Monodentate Ligands in fac<\/em>-[Re(CO)3<\/sub>(5,5\u00a2-Me2<\/sub>bipy)(Amidine)]BF4<\/sub> Complexes: Dependence of Amidine Configuration on the Remote Nitrogen Substituents\u201d; Inorganic Chemistry (Inorganic Chemistry 2010, 49<\/em>, 7035-7045)<\/p>\n

Awards:<\/strong><\/p>\n