Dr. Tharindu Senapathi


Senior Lecturer

B.Sc.(Honors) (USJP), M.Sc.(UCT), Ph.D.(UCT)

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B.Sc. Special Degree (Chemistry) (Honours)– University of Sri Jayewardenapura, Sri Lanka, 2014
M.Sc. (Computational Science) – University of Cape Town, South Africa, 2017
Ph.D. (Chemistry) – University of Cape Town, South Africa, 2021


Physical Chemistry and Computational Chemistry

Undergraduate Teaching:

CHE 106 1.0 Structure and Properties of Matter

CHE 350 0.0 Mathematics for Chemistry

CHE 361 1.0 Advanced Chemical Kinetics

CHE 457 1.0 Molecular Spectroscopy

ICH 355 1.0 Physical Chemistry for Industry II – Solid State Chemistry

ICH 368 1.0 Physical Chemistry for Industry III – Chemical Kinetics

ICH 484 2.0 Quality Assurance, Accreditation and Project Management (Statistical Methods)

CHE 207 2.0 Chemistry Practical Unit (Physical Chemistry)

CHE 315 2.0 Chemistry Practical Unit (Physical Chemistry)

Research interest :

  • Develop computational chemistry and bioinformatics methods to study chemical reactions leading to the structure and function of complex biological molecules that can be traced back to genomic patterns.
  • Apply computational chemistry and bioinformatics methods to study and develop natural products as sources of new drugs.

Selected Publications:

Kevin Naidoo, Tomas Bruce-Chwatt, Tharindu Senapathi, and Malcolm Hillebrand: Multidimensional Free Energy and Accelerated Quantum Library Methods Provide a Gateway to Glycoenzyme Conformational, Electronic and Reaction Mechanisms: Accounts of Chemical Research 2021, 54(22), 4120-4130; DOI:  10.1021/acs.accounts.1c00477.

Simon Bray, Tharindu Senapathi, Christopher B. Barnett, and Björn Grüning: Intuitive, reproducible high-throughput molecular dynamics in Galaxy: a tutorial. Journal of Cheminformatics 2020, 12 (1), 1-13; DOI: 10.1186/s13321-020-00451-6. 

Tharindu Senapathi, Miroslav Suruzhon, Christopher B. Barnett, Jonathan Essex, and Kevin J. Naidoo:  BRIDGE an open platform for reproducible high throughput free energy simulations. Journal of Chemical Information and Modeling 2020, 10 (17), e3731-e3731; DOI:10.1021/acs.jcim.0c00206.

Christopher B. Barnett, Tharindu Senapathi, and Kevin J. Naidoo: Conformational play in the binding of variably glycosylated MUC1 antigen to AR20.5 antibody. Beilstein Journal of Organic Chemistry 2020, 16 (1), 2540-2550; DOI: 10.3762/bjoc.16.206. 

Miroslav Suruzhon, Tharindu Senapathi, Michael Steven Bodnarchuk, Russell Viner, Ian Wall, Christopher B. Barnett, Kevin J. Naidoo, and Jonathan W. Essex: ProtoCaller: Robust Automation of Binding Free Energy Calculations. Journal of Chemical Information and Modeling 2020, 60 (4), 1917-1921; DOI:10.1021/acs.jcim.9b01158.

Tharindu Senapathi, Simon Bray, Christopher B. Barnett, Björn Grüning, and Kevin J Naidoo: Biomolecular Reaction and Interaction Dynamics Global Environment (BRIDGE). Bioinformatics 2019, 35 (18), 3508-3509; DOI:10.1093/bioinformatics/btz107.

Upendra A. Rathnayake, Tharindu Senapathi, Chanaka Sandaruwan, Sanja Gunawardene, Veranja Karunaratne, and Nilwala Kottegoda: Rice bran nanofiber composites for stabilization of phytase. Chemistry Central Journal 2018, 12 (1), 1-7.; DOI:10.1186/s13065-018-0400-y.

Current Affiliations:

Research Associate: Scientific Computing Research Unit, University of Cape Town.

Assistant editor: Vidyodaya Journal of science.

Deputy Proctor: Faculty of Applied Sciences, University of Sri Jayewardenepura.

Contact information

Telephone number: 0717 385 385

Web: Google Scholar/Tharindu Senapathi

Email: tharindunuwan@sjp.ac.lk

Room : 2L035